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Transgenic goats
- New Antithrombin Drug, ATryn, Approved by FDA
ATryn, an anticoagulant, is the first ever biologic product produced by a genetically engineered (GE) animal – a goat. - Several structural motifs cooperate in determining the highly effective anti-thrombin activity of NU172 aptamer
Despite aptamers are very promising alternative to antibodies, very few of them are under clinical trials or are used as drugs. Among them, NU172 is currently in Phase II as anticoagulant in heart disease treatments. It inhibits thrombin activity much more effectively than TBA, the best known thrombin binding aptamer.
Goats as drug factories
- The Land of Milk and Money
A new bioreactor—an animal genetically engineered to produce a therapeutic protein in its milk—may finally be ready to fulfill its long-awaited promise.
Diagram
ATryn (antithrombin [Recombinant]) production process
Source:
Business Wire. (2009, February 06). ADDING MULTIMEDIA ATryn® (Antithrombin [Recombinant]) Approved by the FDA. Retrieved March 12, 2018, from https://www.businesswire.com/news/home/20090206005506/en/ADDING%C2%A0MULTIMEDIA-ATryn%C2%AE-Antithrombin-Recombinant-Approved-FDA
Risks vs Benefits
- Go-ahead for 'pharmed' goat drug
The first medicine produced from a genetically modified animal has been recommended for use in Europe.
Goats excellent models for transgenesis
- Chapter 26 - Transgenic Cloned Goats and the Production of Recombinant Therapeutic Proteins
The clinical use of recombinant therapeutic proteins has increased significantly during the last few decades.
